Everted gut sac model as a tool in pharmaceutical research: limitations and applications
نویسندگان
چکیده
منابع مشابه
مطالعه اثر تداخلی ایندیوم بر جذب روده ای آهن با استفاده از روش everted gut sac
Iron is an essential metal which involves in more cell activities in the form of enzymes and / or other metaloproteins . Indium is one of the toxic elements that may be interfered with iron metabolism . Using this element has increased recently by different industry. Therefore the aim of this investigation was to study int...
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The present study aimed at exploring the potential of the P-glycoprotein (P-gp) transporters as a barrier to the repaglinide (REG) epithelial permeability. In-vitro intestinal absorption models, the everted gut sac, and Caco-2 cell line, were used to study the possible role of P-gp in intestinal transport of REG. In the everted gut sacs, apparent permeability coefficients showed cargo concentra...
متن کاملAn Investigation into the Role of P-Glycoprotein in the Intestinal Absorption of Repaglinide: Assessed by Everted Gut Sac and Caco-2 Cell Line
The present study aimed at exploring the potential of the P-glycoprotein (P-gp) transporters as a barrier to the repaglinide (REG) epithelial permeability. In-vitro intestinal absorption models, the everted gut sac, and Caco-2 cell line, were used to study the possible role of P-gp in intestinal transport of REG. In the everted gut sacs, apparent permeability coefficients showed cargo concentra...
متن کاملمطالعه اثر تداخلی ایندیوم بر جذب روده ای آهن با استفاده از روش everted gut sac
آهن یکی از فلزات ضروری است که در اکثر اعمال سلولی بعنوان کوفاکتور و یا جزئی از ساختمان آنزیم ها و دیگر متالوپروتئین ها دخالت می نماید . از جمله عناصر سمی که ممکن است با متابولیسم آهن تداخل داشته باشد ، عنصر ایندیوم است . در سالهای اخیر مصرف ایندیوم در صنایع مختلف به مقدار بالایی افزایش یافته است، به همین خاطر احتمال مسمومیت با این عنصر وجود دارد . در مطالعه حاضر اثر تداخلی این عنصر بر روی اولین...
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Background: External beam radiotherapy and brachytherapy plays a vital role in the management of cancer cervix. High dose rate brachytherapy is being presently used worldwide for the brachytherapy applications. At present, 2-Dimensional linear array detectors are the most common QA tool used for pretreatment patient specific quality assurance in external beam radiotherapy alon...
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ژورنال
عنوان ژورنال: Journal of Pharmacy and Pharmacology
سال: 2011
ISSN: 2042-7158,0022-3573
DOI: 10.1111/j.2042-7158.2011.01391.x